In Pac-Man vs., Pac-Man must navigate mazes, eating pac-dots, fruit, and power pellets as he dodges hungry ghosts, just like the original--but this time, human players control the ghosts. The lead player, viewing the entire maze on the Game Boy Advance, must avoid the other three players controlling the ghosts on the television screen. To raise the tension factor, the three ghost players can only see part of the maze around their characters. Pac-Man must clear all the pac-dots in each maze to progress to the next level.