PsychoToxic places gamers in the shoes of heroine Angie Prophet who, unbeknownst to her, must save mankind from impending nuclear Armageddon. The year is 2022, the place is New York City and as Angie's role as savior unfolds so too does her understanding of why she is the only one that stands in the way of the Fourth Horseman of the Apocalypse and the destruction of civilization. Throughout the game, Angie continues to discover a series of unique abilities, such as invisibility, the slowing of time and the infiltration of other's dreams, all of which aid her progress.