The story of Mystery Case Files: 13th Skull begins with the disappearance of Marcus Lawson, shortly after moving into a creepy mansion in Louisiana with his wife and daughter. Marcus' daughter, Magnolia, believes her father was kidnapped by the ghost of a vengeful pirate seeking to protect his lost fortune. The locals are terrified of the pirate's curse and it's the players job to interview them, looking for clues and solving the mystery of what happened to Marcus.