The Da Vinci Disappearance will include both single-player and multiplayer content for Assassin's Creed Brotherhood. After the fall of the Borgias in Rome, Leonardo Da Vinci is kidnapped by the Hermeticists, an underground cult dedicated to transforming mankind. Ezio will embark on a relentless quest to recover stolen paintings in order to find Leo before it is too late, discovering two new locations and two new gameplay features along the way.

Xbox 360 (75.87%)